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Phenacetin, a widely used analgesic and antipyretic drug, was first synthesized in 1878 by Harmon Northrop Morse. Derived from p-phenetidine, phenacetin's structure was confirmed through chemical analysis and testing. By 1887, it was introduced into the market by Bayer and quickly became popular due to its effectiveness in reducing pain and fever. Its chemical composition and pharmacological properties have made it a significant compound in medicinal chemistry.
Phenacetin was primarily used to treat mild to moderate pain, such as headaches, toothaches, and menstrual cramps. Its antipyretic properties also made it effective in reducing fever. For many years, it was a common ingredient in over-the-counter pain relief medications and was often combined with other analgesics like aspirin or caffeine to enhance its effects.
Phenacetin was frequently used in combination drugs, such as APC (aspirin, phenacetin, and caffeine) tablets, which were popular for treating pain and inflammation. These combinations provided synergistic effects, improving the overall efficacy of pain relief medications.
Brand: Soarwin
CAS No.: 62-44-2
EC Number: 200-533-0
Molecular Formula: C10H13NO2
Density: 1.1248 (rough estimate)
Melting point: 133-136 °C (lit.)
Boiling point: 132 °C / 4mmHg
Flash point: 2°C